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This unified mechanism underpins the clinical efficacy observed across all FDA-approved GLP-1 RAs, though individual agents differ in pharmacokinetics and the relative emphasis on gastric versus central pathways

Lancet (London, England), 392 (10148), 637649

Stephen Matta

The findings of this meta-analysis suggest that GLP-1 receptor agonists are not associated with an increased risk of gastrointestinal cancers and were not associated with increased gastrointestinal cancer risk and demonstrated pooled estimates below unity for colorectal and liver cancers, findings that should be interpreted as hypothesis-generating rather than confirmatory of cancer prevention (Lingvay et al., 2018

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